Most distributions and DEs already package wine in a set it and forget it configuration. Wine by default has a system wide prefix such that clicking on any exe in the file system automatically runs it on the default prefix. This way of doing things predates wsl by a long time. It is just safer and better practice to setup a new prefix for every software, specially if they are games.
Bazzite comes with wine all setup by default. KDE’s file managerl can integrate running exe with wine on a default prefix automatically.