fiat_lux

1 patient, T2 since mid-30s and now 59, had kidney transplant 2017 after end-stage diabetic nephropathy and fucked glucose control since 2019. The successful cells were endoderm stem cells from him cultivated by mice they injected with his PBMCs that they then made diabetic. So not from cadavers (except mouse cadaver i guess), which is the actual new part here. Intrahepatic implant, and cells from unrelated donor failed that were embedded at the same time. His personalised mouse-donor cells worked well enough to take him off insulin 3 months later.

Wu, J., Li, T., Guo, M. et al. Treating a type 2 diabetic patient with impaired pancreatic islet function by personalized endoderm stem cell-derived islet tissue. Cell Discov 10, 45 (2024).

It’s good news, but you’re entirely correct that the article missed the point entirely. Thanks for the crash course in islet cell therapy!

Looming? Sudan is past the looming stage. When do known verified atrocities reach “current reality” status?

I once looked at a job listing for something with very specialist technical knowledge in specific programming areas, for a Japanese company based in Tokyo (pre-covid so remote wasn’t really a thing yet). Pretty niche stuff and needed at least basic Japanese language skills too, so I assumed it would pay ok - even if it wasn’t good or great in comparison with jobs where i was.

After conversion it worked out to be around USD$40k a year, which is probably just over 1/3 of what it would pay at minimum elsewhere. More like 1/4 or less for Silicon Valley type locations, but the rent for a tiny Tokyo shoebox is about the same price even if food is a cheaper. There was no way I was applying for that.

It isn’t just about a weak yen, it’s much more about hugely underpaying people.

Sounds like we had the same programmers. I feel you, Kairos.

I’ve never felt so conflicted. On one hand, I want to hug the puppy. On the other, sand. It makes me sad like porcupines do. Why won’t they let me love them?

That is not a level of power I officially possess, but it is a level of power that I am able to unofficially implement for the people who solely report to me. I am also able to tailor their roles and responsibilities to whatever causes them the least pain because their job titles are extremely non-specific, which is very helpful for both of us.

Both manager and non-managers are economically coerced into providing our time and energy. I try my best to reduce that burden for as many people as I can without being noticed by the people who are willing to suck the life out of others for personal gain.

The people who are marginalised by the process are the ones who will be doing the real suffering.

Hobbies indicate interest and aptitude. Someone who collects things might enjoy jobs and tasks related to organisation but not necessarily enjoy highly collaborative work that requires many meetings, whereas someone who enjoys team sports might enjoy the more collaborative social meeting type work instead of solo detailed organisation etc.

It is far from the first thing I would use as a hiring choice, but it does give me an idea of questions I might ask someone to figure out what would make them happiest.

The centerpoints of major waterways and roads are often the places with the most conflict, especially when it’s good fertile land that someone might want to live in. Different religious sects have had major presences in the region, some even established there - the first Christian Roman Emperor was born nearby. They’re also positioned directly in the path of many cultures, both ancient and modern, attempting to increase the size of their own Empires.

The land was built on conflict.

While humans continue to choose competition instead of collaboration with other slightly different humans, it will remain in conflict - much like other strategic arable accessible locations we see in the headlines.

Climate change will slowly increase the amount of land affected by conflict, when resource shortages become more severe from natural disasters; but the flashpoints are places like the Balkans.

I’m pleasantly surprised they didn’t start up again sooner. But, like, in the tiniest glimmer of silver lining kind of way.

Edit: tl;dr We all live in a shitty Civilization game but with less predictable players.

deleted by creator

In places that were invaded, resistance were thrown from the top of buildings after they were interrogated, their bodies were left there to be collected by whoever dared. At night all you could hear were their screams while they were being tortured in cellars by the Gestapo. Dissidents were hanged from lampposts in the main street and left as warnings. The concentration camps were often in the middle of the town, not placed at a distance to avoid offending the locals.

And the next generation in those places grew up right next to those concentration camps and mass graves. They were raised by physically and psychologically scarred people, in places that were not funded by the Marshall Plan reconstruction funds that even West Germany received. Decades later there was still rubble and half destroyed buildings.

I appreciate there is much trauma involved in losing any family, friends or community members to war, or to experiencing the bombs being dropped around you. But, I think the level of cruelty and fear experienced by invaded regions was next level. And I don’t think Germans generally understand the details of what life was like for the places that were occupied - but that is only my suspicion. I can’t understand how else the AfD could discuss deportations or receive such a huge proportion of the vote.

Neither Axis aligned country tesidents nor the invaded would cherish reliving it, but they have had and continue to have very very different experiences as a consequence of the war.

There’s nothing more human than killing each other to stop war, either.

The human species’ best creations have been through collaboration on new ideas and projects, but we keep going back to the old competitive methods that have clearly demonstrated that they don’t make good long term solutions. We just don’t learn.

Thanks for standing up to Nazis. It gives those of us who had family experience the horrors wrought by fascists in WW2 hope that Germans haven’t been won over again by the same poisonous ideas.

The word “fossil” could have made an appearance in this article title, and yet it is noticeably and somewhat misleadingly absent.

Can we… see them?

Edit: some quick math, the minimum recommended space between trees is 3m, 200 million of those is 600km² / 148k ac , which would make the space required bigger than 17 countries (larger than Andorra but very slightly smaller than Saint Lucia). They have a blog with their tree planting updates but I wish there were more photos.

It seems to me that if we’re talking about addressing starvation, war and political instability, then allowing the demographic who largely are responsible for food production and family health to lead and participate in a single (probably 1 hour long weekly) conversation on TV about those issues might be a key step to better understanding the core problems facing them and increasing democracy by ensuring 50% of the population is heard. Problems can’t be properly addressed until they are accurately identified, and missing 50% of the the population’s voices about problems won’t help.

Also, for just 6 people to address a huge communication gap on a national scale in multiple media formats that can reach a population that is largely illiterate? That sounds like a hugely impactful and solid strategy for organizing important community projects and initiatives that increase stability.

What specific projects would you suggest to these 6 women that address the problems you have identified and make a larger positive impact than their current efforts?

Is it possible that people with lived experience might have a better knowledge of their needs and the next steps in fixing their own problems than you?

More important things to worry about than journalism on issues that affect (at least half) the entire population? Issues that have never been acknowledged institutionally due to women being denied employment and education? In a country that ranks fourth lowest for gender equality globally, maternal and infant mortality rates? Do you really think Somali women have nothing to add to these conversations that hasn’t already been covered?

Adding to this: Bilan’s self introduction video (1 min 41 sec, hardcoded English subtitles). Sorry, no transcript for those who rely on real text. I wanted to watch this but I was left with no information in the article on how or if English speakers even could.

The entire Western media’s approach to African nation reporting also enrages me. The continual insistence of media (especially UK based) on choosing photos to remind us that black Africans are poor and “backwards” is shameful racism. It’s no wonder that African nations are distancing themselves economically and ideologically from the West when their colonizers allies’ media machines continue to treat them this way.

“Before the war, I used to play with my friends,” he said. “I can’t play because of my injury. I can’t play, and I don’t have friends, and I don’t have anything.”

Acquired disability is a problem that will exponentially increase with climate change and industrial pollution. Wildfires create smoke that triggers heart and lung problems. War creates amputations and trauma. Drought increases food prices and creates malnutrition. Floods spread malaria and infection and other poisons. The stress on the body from any of those can in turn trigger other underlying health conditions and other genetic inefficiencies.

If we don’t stop spending all our resources on killing each other and start spending them on helping each other, more people won’t have anything. Just like this 12 year old child.

5 months ago, mod, Removed Post Reddit is dangerous. The admins are out of control. Humanity needs a viable alternative. – Blog covering the Reddit admins retaliating against me, reason: rule 4

I thought I recognised your name. I happen to be experimenting with my own gut-brain axis, so I recall skimming your project.

Here’s the problem.

Reddit will not act on people insulting your personal project unless they consider it a legal, financial or reputational risk not to do so.

Lawyers will not take on your case unless they think there is a solid chance of financial or reputational gain beyond the standard hourly fee. They are telling you in the most professional way possible that they see no merit in spending their time on your theory’s reputation. My suspicion is that they feel your… zeal and passion for your theory is bordering on fanatical. They don’t want to work with fanatics.

Without substantial and demonstrable effects on your finances, what you are left with is just some low level insults on the internet, and one or more relatively anonymous individuals who know that trolling you will get them the reaction they desire. If you continue to react like this, they will continue to try to get a reaction from you.

These concepts have been explained to you previously.

I understand that you believe you have found answers that have previously been ignored by medicine. I know how that feels. But research is already being done in this area and will take time to bear fruit.

Additionally, continuing to post your site as a response to threads that lightly touch on adjacent topics does not do much more than highlight you as a self-promoting spammer who might be fun to troll. It also does not endear you to admins or mods, let alone anyone who might positively engage with the topic. Threads like this let trolls know their efforts to annoy you are working extremely well. Using your real name to do so just makes it much easier for them to harass you.

I do not like victim blaming, but I hope you are able to reflect on how your reactions and inability to let minor insults slide might be compromising your ability to have your project and theories taken more seriously and treated with respect. If you are very serious about legal recourse, then regrettably you need to monetize your project and accurately document negative effects caused by specific people.